• br Marginal zone lymphoma Marginal zone lymphoma MZL compris

  2019-09-16

  

  Marginal zone lymphoma Marginal zone lymphoma (MZL) comprises three lymphoma entities that arise from the marginal zone surrounding the germinal center: extranodal MZL or mucosa-associated lymphoid tissue (MALT), splenic MZL, and nodal MZL. Deep sequencing of nodal MZL patients found that 5/35 (1

• In general cellular senescence is considered a programmed

  2019-09-16

  

  In general, cellular senescence is considered a programmed response to stress that can be activated by oxidative stress, irradiation or action of substances or drugs. These stressors cause DNA damage and, through the action of specific proteins (p53 and p21), lead to cell senescence (di Fagagna, 200

• Isotretinoin DSBs can be repaired by two major pathways cano

  2019-09-16

  

  DSBs can be repaired by two major pathways: canonical non-homologous end-joining (c-NHEJ) and homologous recombination (HR) (Chapman et al., 2012). c-NHEJ comprises two sub-pathways, a resection-independent process and a resection-dependent process, and can rejoin break ends with little or no sequen

• br Results and discussion br Conclusion A new series

  2019-09-16

  

  Results and discussion Conclusion A new series of 2-mercapto-quinazolin-4-one analogues is designed and synthesized to possess electron withdrawing or donating functional groups (Cl or CH3O) at position 6- or 7-, 4-methoxyphenyl function at position 3. The 2-mercapto function is used to connec

• Interaction between neutrophils and ECs represents

  2019-09-16

  

  Interaction between neutrophils and ECs represents the first step of the cellular phase of the inflammatory response, and provide the best condition for the transfer of the PMNL-derived LTA4 to the ECs, leading to the transcellular formation of cysteinyl-LTs. It is intriguing therefore to think that

• Midazolam oral clearance is used for characterization of

  2019-09-16

  

  Midazolam oral clearance is used for characterization of both intestinal and hepatic CYP3A activity. However, the identification and subsequent use of metabolic markers of CYP3A activity can eliminate the need for unnecessary administration of probe drugs such as midazolam. Such metabolic markers wo

• Enlarging the ligand binding pocket by reduction of

  2019-09-12

  Enlarging the ligand-binding pocket by reduction of the size of the residue F435 switched DES to an agonist indicating that F435 is involved in mediating the antagonistic effect of DES (Fig. 7E) [13].

• In the present study we have examined an

  2019-09-11

  In the present study, we have examined, an alternative approach for introduction of Hyp into bacterial, non-animal collagens.

• TKI discontinuation studies demonstrate that

  2019-09-10

  TKI discontinuation studies demonstrate that a portion of TKI-treated CML patients remain in remission for up to 3 years, although long-term risk assessment is still necessary (Bansal and Radich, 2016).

• Social memory is encoded within certain sites but

  2019-09-09

  Social memory is encoded within certain sites, but meaning depends upon an interpretant (such as a tourist) being able to decode the signs.

• To function as Ub ligases E proteins

  2019-09-07

  To function as Ub-ligases, E3 proteins must interact with E2s. As compared to the extensive studies on E3s, functional studies on E2s are relatively rudimentary in higher plants.

• Compounds and administered orally to fasted

  2019-09-06

  Compounds , , and administered orally to fasted Harlan Sprague-Dawley rats 1h prior to trigeminal stimulation, decreased extravasation in this model in a dose-related manner, with an estimated ID of 1, 10 and 100μg/kg, respectively (determined 15min after stimulation, ).

• There is an opposite opinion indicating that EphB plays

  2019-09-05

  There is an opposite opinion indicating that EphB plays a role as cancer suppressor.

• Organ fibrosis is thought to

  2019-09-04

  Organ fibrosis is thought to be initiated by repeated or chronic epithelial injury.

• The liposomes as a FDA approved

  2019-09-03

  The liposomes, as a FDA-approved drug delivery carrier, have been widely utilized for drug delivery [32], [33], [34].

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