• Cell swelling stimulates the release of certain amino acids

  2020-02-24

  

  Cell swelling stimulates the release of certain amino acids, in particular the non-protein amino zd 14 taurine, via a pathway which has the characteristics of a channel rather than a carrier [54], [69]. Indeed, on the basis of pharmacological inhibition, it was suggested that volume-activated tauri

• These findings further extend our knowledge of how P

  2020-02-24

  

  These findings further extend our knowledge of how P4 and/or E2 can mediate anxiety and fear responses. Female rats in behavioral estrous and ovx rats administered systemic P4 and/or E2 demonstrated significantly less anxiety in the open field and/or elevated plus maze, compared to diestrous rats, a

• The significant CRF increase in the DS and

  2020-02-22

  

  The significant CRF increase in the DS and the overall changes in the CRF system observed in the VM and DS during the development of sensitization suggest that this neuropeptide (and possibly urocortin) contributes to the specific molecular alterations occurring in the mesolimbic pathway that suppor

• br Oxidoreductase like MEM for prodrug activation br Future

  2020-02-22

  

  Oxidoreductase-like MEM for prodrug activation Future outlook Although MEM-mediated prodrug activation has been performed by different MEMs and prodrugs, and their effectiveness have been proved in vivo, only a few types of MEMs or prodrugs have been explored in prodrug activation until now [2

• Haj Yahya et al applied native chemical ligation for

  2020-02-22

  

  Haj-Yahya et al. [52] applied native chemical ligation for the construction of diubiquitin probes. They attached a cysteine residue to the lysine side chain of the proximal ubiquitin and ligated the distal module using the C-terminal thioester of ubiquitin. Elimination of the sulfur Risedronate mg

• The Nile tilapia Oreochromis niloticus is an important farme

  2020-02-22

  

  The Nile tilapia (Oreochromis niloticus) is an important farmed fish with an XX/XY sex-determining system. The availability of the whole genome sequence of tilapia and tissue transcriptomes (Brawand et al., 2014), together with its gonadal transcriptomes at different developmental stages (Tao et al.

• Classical DHFR inhibitors such as methotrexate

  2020-02-22

  

  Classical DHFR inhibitors such as methotrexate (MTX) bind tightly to the enzyme and possess adequate clinical pharmacokinetics. MTX bind to the DHFR binding site through the formation of hydrogen bonds with Asn64, Lys68, Arg28, Arg70, Val115 and Ile7 amino ropinirole hydrochloride receptor residues

• Citrus plants are of great interest

  2020-02-22

  

  Citrus plants are of great interest because they contain large amounts of flavonoids, and citrus fruits and their juices are consumed in large quantities around the world [18]. The flavonoid contents and profiles of citrus juices vary greatly with the type of fruit. It has been determined that citru

• br Materials and methods br Results and discussion

  2020-02-22

  

  Materials and methods Results and discussion Conclusions Conflict of interest Acknowledgments This work was financially supported by the National Natural Science Foundation of China (31302162, 31171762), National High Technology Research and Development Program of China (863 Program,

• Magnetic interactions between metal ions are usually describ

  2020-02-22

  

  Magnetic interactions between metal ions are usually described by superexchange via intermediate ligands. Although the general principles of the superexchange mechanism are essentially the same for d and f ions, calculations of exchange parameters for lanthanides are more difficult than for transiti

• The use of recombinant ER and

  2020-02-22

  

  The use of recombinant ERα and ERβ binding assays offers a relatively inexpensive, rapid technique for screening compounds for potential direct b-Casomorphin (1-3) receptor modulatory activity and understanding the mechanisms of existing herbal medicines. For background on the protein production sys

• The action of pt PGE as an

  2020-02-22

  

  The action of 17-pt-PGE2 as an EP1 receptor agonist [34] was demonstrated in several experimental settings, including cancer, neurons, vascular system, kidney and was confirmed by application of EP1 receptor selective antagonists [35], [36], [37], [38], [39], [40], [41]. Receptor binding studies in

• Enhanced responses to varying concentrations of bronchoconst

  2020-02-22

  

  Enhanced responses to varying concentrations of bronchoconstrictors, such as MCh, and airway obstruction are characteristic of LB Agar Miller and common to other clinical states, including chronic obstructive pulmonary disease, lung transplantation, and infection- or chemical agent-induced airway i

• The lack of effective strategies aiming to

  2020-02-22

  

  The lack of effective strategies, aiming to directly increase the neuronal survival, is reflected by the fact that the only available therapeutic interventions are indirect. They consist of acute therapeutic interventions involving chemical and/or surgical removal of the thrombotic clot (Taqi et al.

• VKGILS-NH2 receptor The kinase activity of DNA

  2020-02-22

  

  The kinase activity of DNA-PKcs is essential for NHEJ, but the exact role of the enzymatic activity of DNA-PKcs plays in NHEJ is not fully understood [57]. In vitro, DNA-PKcs can phosphorylate each of the canonical NHEJ factors including Ku70/80 [58], [59], XRCC4 [60], [61], VKGILS-NH2 receptor IV

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