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In this study cell migration in response to LTD
2019-10-22
In this study, cell migration in response to LTD4 exhibited a typical bell-shaped dose-response curve with optimal activity at 10 nM. However, the effect of inhaled CysLTs on airway inflammatory cells in vivo has not been widely reported to date, therefore, the role of CysLTs in the development of a
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Index Kit 1 br Cyclin dependent kinases control
2019-10-22
Cyclin-dependent kinases control more than cell cycle CDKs’ roles conducting the concert of Index Kit 1 was first revealed in the context of the tumor suppressor Rb, phosphorylation of which by CDK4 or CDK6 inactivates it loosing the transcription factor E2F [1], [12], [15]. Discovery of other c
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The objective of the present study was
2019-10-22
The objective of the present study was to investigate the role of the CRF system in the neuroadaptations associated with nicotine dependence. To this aim, the regulation of the gene expression of CRF and its receptors was assessed in Baicalin regions belonging to the reward pathway using a model of
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Flexible alignment of isopropylphenylaminobenzimidazole with
2019-10-22
Flexible alignment of 7-isopropylphenylaminobenzimidazole 16 with the lead PF-3845 1 was performed using MOE. It was found that the aryl group of compound 16, exemplified as a yellow circle in Figure 2, overlapped well with the corresponding alkyl chain of compound 1 as well as the other key functi
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Importantly a crucial role of transcription factor SP in med
2019-10-22
Importantly, a crucial role of transcription factor SP1 in mediating the anti-lung cancer effect of XJD was found in this study. Our results suggested that the inhibition of SP1 was required to mediate the inhibitory effect of XJD on the growth of NSCLC cells. Nuclear transcription factors SP1 is as
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Several effective strategies have been
2019-10-22
Several effective strategies have been developed to design activatable MR probes according to the Solomon, Bloembergen and Morgan (SBM) theory, including modulation of the number of inner-sphere water molecules (q), the rotational tumbling time (τ) and the residence lifetime of inner-sphere water mo
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A comparative analysis of the cleavage
2019-10-22
A comparative analysis of the cleavage activity of different forms of the BoNT/A endopeptidase in reduced conditions with SNAPtide and full-length SNAP-25 substrate is summarized in Fig. 5, Fig. 6. The BoNT/A LC was found to be the most active against SNAPtide, a small peptide segment of the SNAP-25
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Mother rats acutely treated with quinpirole and mg
2019-10-22
Mother rats acutely treated with quinpirole (0.5 and 1.0 mg/kg) decreased the pup exploration time but increased the object exploration, so they showed a significantly lower pup preference ratio. They also showed impaired maternal performance in the home cage, consistent with our previous study (Zha
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Besides being an energy storing tissue
2019-10-21
Besides being an energy storing tissue, adipose tissue acts as an active endocrine organ that secretes a number of biologically active adipokines involved in multiple physiological processes such as inflammation and lipid and glucose metabolism, with direct and indirect effects on reproduction [15,1
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br Results and discussion br Conclusion Recent studies
2019-10-21
Results and discussion Conclusion Recent studies showed that EGFR signaling is involved in inflammatory response in several inflammatory conditions. The normal inflammatory macrophage MRS 2578 show EGFR-dependent production of inflammatory mediators. Nevertheless, the development of EGFR inh
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Advances in the total chemical synthesis of ubiquitin
2019-10-21
Advances in the total chemical synthesis of ubiquitin have enabled the efficient synthesis of new and improved ubiquitin-based reagents. Using an optimized linear synthesis, ubiquitin can now be easily obtained in high yield and purity [35]. Using this synthetic methodology, ubiquitin can be functio
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br GPCRs form heterotetramers In addition to homodimers and
2019-10-21
GPCRs form heterotetramers In addition to homodimers and heterodimers, for several family A receptor heteromers, experimental evidence supports the presence of higher order rearrangements as tetrameric structures, comprised of two different homodimers, each able to signal with its preferred G pro
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br Results br Discussion In addition to contributing to amin
2019-10-21
Results Discussion In addition to contributing to amino MOG (35-55) receptor and lipid biosynthesis, mitochondrial metabolism affects nucleotide biosynthesis. Indeed, many components that contribute to both pyrimidine and purine bases are derived directly or indirectly from mitochondria. Besi
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As a basis for the DDR substrate identification approach
2019-10-21
As a basis for the DDR1 substrate identification approach detailed below, we first set out to perform 2D-gel electrophoresis with lysates isolated from collagen-stimulated human breast cancer MDA-MB-231 98 2 mg overexpressing DDR1 (b-isoform). This allowed us to determine whether DDR1 is not only c
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br Subjects and methods br Results br Discussion In
2019-10-21
Subjects and methods Results Discussion In the present study, we found significantly increased CSF levels of IL-4, IL-5, IL-9, IL-10, TNF-α, CXCL8/IL-8, and VEGF-A together with significantly higher detection rates of IL-6, GM-CSF, PDGF-BB and IL-1ra in IHP patients compared with OND patien
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