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Our results indicate that C CoA is formed in
2020-02-04
Our results indicate that C75-CoA is formed in the hypothalamus following stereotaxic injection of C75. Inhibition of hypothalamic CPT1 by C75-CoA in vivo, as seen in our experiments, is independent of the putative inhibition by malonyl-CoA, which may be formed after the action of C75 either on FAS
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The regression also revealed a significant association betwe
2020-02-04
The regression also revealed a significant association between admission selectivity (SELECT) and exam pass rate (PASS%) (p lipoxygenase inhibitor serve as an indicator of a student’s ability to learn and their aptitude for academic success. These same qualities likely enable more selective schools
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br Conflict of interest br Acknowledgements This work was su
2020-02-04
Conflict of interest Acknowledgements This work was supported in part by JSPS KAKENHI Grant Number 26292031. We thank Nissan Chemical Industries, Ltd. for the gift of the sample of fluralaner. Introduction As one of the most common cancers in southern China and southeast Asia, nasopharynge
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Not all of the biological activities exhibited by progestoge
2020-02-04
Not all of the biological activities exhibited by progestogens (Table 1) are mediated via binding to SRs. For example, the anti-estrogenic action of progestogens in the Forsythoside A is due to the progestogen-bound PR suppressing ER gene expression, and consequently the ability of the cell to resp
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T 705 ERR is constitutively active in the absence of endogen
2020-02-04
ERRγ is constitutively active in the absence of endogenous ligand. However, several synthetic ligands that can repress or induce ERRγ function by disrupting ERRγ-coactivator interactions have been reported to date. The estrogen receptor modulators diethylstilbestrol (DES) and 4-hydroxytamoxifen (4-O
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Although information regarding the influence of PGE on cardi
2020-02-04
Although information regarding the influence of PGE2 on cardiac fibroblast cell growth is sparse, the effect of PGE2 on other cell types has been studied extensively, particularly in cancer and cancer cell lines where COX-2 is over-expressed. Constitutive high levels of COX-2 expression have been no
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br The synthesis of these antagonists
2020-02-04
The synthesis of these antagonists relied heavily on Stille and Suzuki coupling reactions. The preparation of the required building blocks is presented in . Reduction of ethyl 6-bromo-2-pyridinecarboxylate with diisobutylaluminum hydride in tetrahydrofuran followed by treatment with triisopropylsi
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During the course of enzymatic digestion protein is
2020-02-04
During the course of enzymatic digestion, protein is digested into large peptides and these large peptides are then further digested into small fragments. αs1-Casein f15–39, which contains 25 amino ABT888 residues was the longest iTRAQ-labelled peptide identified in the samples digested with GE at
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Organometallic compounds exhibited remarkable potential for
2020-02-04
Organometallic compounds exhibited remarkable potential for the development of new cancer drugs not only due to the direct cytotoxicity but also to the drug targeting and active anticancer immune response ability [4]. Among the organometallic compounds, ferrocene is one of the most well-known compou
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Several lines of evidence suggest
2020-02-04
Several lines of evidence suggest that the anxiety provoking behavioral effects of CRF involve CRF1 receptors. CRF1 knockout mice show increased anxiolytic-like activity in the elevated plus maze and a tendency to enter the illuminated region of a light–dark box [49], [52]. In addition, studies usin
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In the context of our ongoing studies to define
2020-02-04
In the context of our ongoing studies to define the phytochemical and biological properties of oxyprenylated secondary metabolites of plant and fungal origin, we wish to report herein the investigation on the interaction of some natural and semisynthetic O-alkylcoumarins with promising ChE inhibitor
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SPR was used to measure biomolecular kinetic interactions be
2020-02-03
SPR was used to measure biomolecular kinetic interactions between TERRA G-quadruplex and ligand in the present study. SPR is a widely used method, but cannot tell which specific type of interaction happened. Compounds with similar structures probably have similar mechanism of interaction, while com
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br Transparency document br Results and Discussion br Experi
2020-02-03
Transparency document Results and Discussion Experimental Procedures Acknowledgments The casein kinase 1 (CK1) family consists of at least seven different gene products, often referred to as isoforms (α, β, γ1, γ2, γ3, δ, ε, with splice forms described for CK1α, γ, and ε (reviewed in )
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In bone PGE exerts both anabolic and catabolic effects
2020-02-03
In bone, PGE2 exerts both anabolic and catabolic effects [6], [7], [8], [9]. Administration of PGE2 to mice lacking each of the four prostanoid receptors identified EP4 as the primary mediator of PGE2-induced bone formation [10]. While the role of EP1 in osteoblastic differentiation and bone metabol
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Ultrasound is an acoustic wave with
2020-02-03
Ultrasound is an acoustic wave with a frequency >20 kHz that needs a medium to propagate [20]. Accompanied by the spread of an ultrasonic wave, a series of alternating cycles of compression and rarefaction emerge in the liquid medium. During the rarefaction cycle, microbubbles are formed because of
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