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br Acknowledgments br Introduction Cysteinyl leukotrienes Cy
2020-03-27
Acknowledgments Introduction Cysteinyl leukotrienes (CysLTs), LTC4, LTD4 and LTE4, are 5-lipoxygenase pathway metabolites of arachidonic PRIMA-1 australia and deeply involved in bronchial asthma via activation of CysLT1 receptors [1], [2]. Specific CysLT1 receptor antagonists, including pranl
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In this study for the
2020-03-27
In this Irinotecan study, for the first time, we demonstrated that herb-derived LFS-01 induces concomitant mitophagy and apoptosis in lymphoma cells. Through various biochemical studies, we showed that LFS-01 directly targets the sulfhydryl (-SH) group of a conserved cysteine in the nuclear export
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Cryoprotectant equilibration and the response to ice concent
2020-03-27
Cryoprotectant equilibration and the response to ice concentrated media are the two facets of cellular cryobiological protocols most commonly covered by mathematical modeling. In these models, SB525334 sale are typically assumed to have uniform, spatially independent extracellular concentrations an
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Goel et al reported study
2020-03-27
Goel et al. reported study of 7,8-diacetoxy-4-methylcoumarin (DAMC) 63 and its thiocoumarin derivative 7,8-diacetoxy-4-methylthiocoumarin (DAMTC) for their effect on human non-small cell lung cancer A549 cells. The study suggested that the 7,8-diacetoxy-4-methylcoumarin (DAMC) 63 downregulates Bcl-x
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Synthetic peptides have proven highly valuable in
2020-03-26
Synthetic peptides have proven highly valuable in replicating the characteristics of collagen and in defining the sites on collagen essential for binding and studying protein–collagen interactions. There are, however, disadvantages to synthetic collagen-like peptides. First, the thermal stability of
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br Materials and methods br Results
2020-03-26
Materials and methods Results and discussion Conclusions In this study, we have investigated the possibility that hierarchical phosphorylation by CK2 may play a role in cellular signal transduction. Hierarchical phosphorylation by CK2 requires multiple consensus determinants with specific s
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A recent report has shown
2020-03-26
A recent report has shown that C. elegans homozygous for a point mutation within the HORMA domain of HTP-1 (M127K), which disrupts its association with chromosome axes, displayed an extended zone of PLK-2 localization to PCs in response to asynapsis (Silva et al., 2014), which, as we show here, is a
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This relative lack of ET expression
2020-03-26
This relative lack of ET-1 expression in highly malignant epithelial Lapatinib Ditosylate could be explained by marked cellular anaplasia and cellular dysfunction; we also suggest that the high levels of VEGF, which have been evidenced in highly malignant mammary tumours (Restucci et al., 2002) may
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In glioblastoma methylation of pMGMT is predictive of the
2020-03-26
In glioblastoma, methylation of pMGMT is predictive of the efficacy of temozolomide with an increased survival [22], [23], [24], [25]. As in glioblastoma [24], [26], [27], [28], pMGMT methylation assessed by pyrosequencing (with immunochemistry, IHC) is the most effective and reproducible technique
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br Competing interests br Acknowledgements br Introduction D
2020-03-26
Competing interests Acknowledgements Introduction Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) in biomembranes to produce phosphatidic [D-Lys3]-GHRP-6 (PA) [1], [2], [3], [4], [5], [6]. To date, ten mammalian DGK isozymes (α, β, γ, δ, ε, ζ, η, θ, ι and κ) have been identi
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DGK is highly expressed in skeletal muscle which is
2020-03-26
DGKδ is highly expressed in skeletal muscle [7], which is a primary target of insulin for glucose disposal [14]. Notably, Chibalin et al. reported that DGKδ contributes to hyperglycemia-induced peripheral insulin resistance and that decreased protein levels of DGKδ in skeletal muscle attenuated gluc
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Introduction Primitive neuroectodermal tumors PNETs are mali
2020-03-26
Introduction Primitive neuroectodermal tumors (PNETs) are malignant, small round cell tumors of neural crest origin which typically arises from bone or soft tissue in the trunk/axial skeleton/paraspinal regions in adolescents and young adults and comprises of 50% cases with local recurrence and met
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br Concluding remarks br Transparency
2020-03-26
Concluding remarks Transparency document Acknowledgements Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award number P30CA033572 (RS). The content is solely the responsibility of the authors and does not neces
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br Activatable optical imaging probes Optical fluorescence i
2020-03-26
Activatable optical imaging probes Optical fluorescence imaging, which directly detects photons emitted from fluorescent probes, has become as a powerful analytical method to study biological processes both in vitro and in vivo. It is characterized by high sensitivity, is free of radioactive irra
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br Cysteine proteases as molecular targets for trypanosomati
2020-03-26
Cysteine proteases as molecular targets for trypanosomatid diseases Approaches relying on a molecular target, such as SBDD and target-based screening, have supported outstanding scientific developments in current pharmaceutical R&D. By integrating experimental and computational methods, these str
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