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Activating GSK signaling to inhibit PK signaling during isch
2020-08-08
Activating GSK3β signaling to inhibit PK signaling during ischemia/reperfusion (I/R) is protective of WM ischemic injury. Glycogen synthase kinase (GSK3), which was the first substrate identified for AKT [44], is inhibited by AKT phosphorylation at positions S9 and S21 [45]. When GSK3β is active, it
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In terms of downstream kinases in the
2020-08-08
In terms of downstream kinases in the MAPK pathway, MEK mutations have been mainly identified in melanoma, and also in ovarian cancer cell lines and gliomas34, 35. Generally, all of the upstream mutations can lead to ERK protein hyperactivation, which is responsible for a series of ERK-signaling-reg
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Heterologous expressed EhDNAligI is able to carry out the
2020-08-07
Heterologous expressed EhDNAligI is able to carry out the three conserved steps of DNA ligation. EhDNAligI forms a ligase–AMP intermediate and a stable complex with a double stranded DNA nick containing a downstream 5′-phosphate group, but not with 5′-hydroxyl or double stranded DNA. The discriminat
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Based on the results of using the
2020-08-07
Based on the results of using the heterologous host system, we further analyzed the C598-0466 patterns of MiDGATs. Nitrogen starvation stress was used as an inducer, because TAG synthesis in microalgae is highly dependent on the varying environmental conditions. Of the three MiDGAT genes, MiDGAT2A
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ANP and BNP are markers
2020-08-06
ANP and BNP are markers for the clinical diagnosis of hypertrophy and cardiac insufficiency, and they can predict the severity and prognosis of the disease [25,26]. In addition, studies have shown that ANP, BNP, and β-MHC are associated with hypertension, myocardial infarction, cardiomyopathy, and m
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Significant potential differences among pesticide enantiomer
2020-08-06
Significant potential differences among pesticide enantiomers may warrant registration of a single enantiomer product or an enriched mixture of the active enantiomer instead of the racemic mixture (Liu and Tang, 2011). In Switzerland and the Netherlands, bv8 australia like mecoprop and dichlorprop h
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Nearly years ago the first two enzymes
2020-08-06
Nearly 60years ago, the first two cyclic amp function which catalyze the phosphorylation of proteins were discovered [1]. Protein phosphorylation was originally identified as a regulatory mechanism for the control of glycogen metabolism. Today it is clear that protein phosphorylation regulates most
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BAY 41-8543 Site specific drug delivery using therapeutic im
2020-08-06
Site-specific drug delivery using therapeutic implants offers significant advantages over systemic administration of drugs. Admittedly, pill-based drug administration is more patient-compliant, non-invasive, and most convenient in the majority of cases of drug delivery. However, localized drug deliv
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br Materials and methods br Results br Discussion In the
2020-08-05
Materials and methods Results Discussion In the present study, we provide evidence that sitagliptin has protective effects against retinal EC dysfunction triggered by inflammatory conditions. Using primary cultures of retinal EC, we demonstrate that sitagliptin prevents the negative impact
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Our present study examined the effects of depleting macropha
2020-08-05
Our present study examined the effects of depleting macrophages in a spontaneous model of LN, while also circumventing any developmental defects by avoiding genetic manipulation. Although the mice were sacrificed before the control mice reached extremely high levels of proteinuria, we believe the re
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To the best of our knowledge this is the
2020-08-05
To the best of our knowledge, this is the first association study to analyze COMT Val158/108Met and the ROCF immediate and delayed scores in veterans with PTSD. The significant difference in ROCF immediate and delayed scores was detected between different COMT Val158/108Met genotype groups in vetera
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br Introduction Gas hydrates are crystalline solid
2020-08-04
Introduction Gas hydrates are crystalline solid compounds in which gas molecules (called guest molecules) are surrounded by water molecules, forming a regular cavity crystalline structure. Gas molecules with a desirable shape and size such as methane, ethane, propane, carbon dioxide and etc. can
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br The desire for COTS products and some potential
2020-08-04
The desire for COTS products––and some potential problems There are also technological reasons in support of the use of OTS products. For example, Dawkins and Riddle (2000) point out that the relatively small safety-related systems market cannot sustain the rate of technological advancement stimu
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Brg is a core unit of BAF
2020-08-04
Brg1 is a core unit of BAF complex and is required for the self-renewal and pluripotency of ESCs (Ho and Crabtree, 2010). We confirmed the interaction of DPF2 and BRG1 by immunoprecipitation and showed that these proteins extensively co-localize in the genome. Although both Brg1 and Dpf2 positively
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Results from both hepatic and renal
2020-08-04
Results from both hepatic and renal microsomal catalytic activity and Western immunoblotting showed no significant difference between retinol and the control groups for CYP2E1. The liver displayed approximately double the CYP2E1 catalytic activity when compared to the kidney. Differential CYP2E1 act
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