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br Results br Discussion GPCRs recognize a broad range of
2020-09-27
Results Discussion GPCRs recognize a broad range of molecules with a vast chemical Tigecycline through different mechanisms. Our understanding of the recognition of lipid mediators by GPCRs primarily comes from the structural studies of receptors for lysophospholipids and endocannabinoids incl
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The notion that a small subset of inducible
2020-09-27
The notion that a small subset of inducible cellular transcripts, encoding immunological important factors, is translocated across the nuclear envelope by the karyopherin CRM1 is gaining support from various recent studies. For example, experimental evidence has been provided demonstrating that the
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br Material and methods br
2020-09-27
Material and methods Results Diagrammatic representations showing the bilateral injection sites in the BNST of all animals used in the present study are presented in Fig. 1. Discussion The present results provide the first evidence that both CRF1 and CRF2 receptors in the BSNT are involve
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Medroxyprogesterone synthesis br Results On the th day the h
2020-09-27
Results On the 8th day, the horizontal (Fig. 1) and vertical locomotor activity (Fig. 2) and the dorsal (Fig. 3) and Medroxyprogesterone synthesis striatal dopamine release (Fig. 4) increased significantly in nicotine-treated rats, compared with the saline-treated rats. Tukey post-hoc test revea
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Stress is usually comprehended as an event affecting mainly
2020-09-27
Stress is usually comprehended as an event affecting mainly the HPA axis and initiating the alarm reaction represented by activation of the adrenal medulla. This means that the levels of related hormones and neurotransmitters are significantly elevated during and after the stress. CRF, following its
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Data presented herein suggest that
2020-09-27
Data presented herein suggest that competent IL-18BP production in epithelial clofibrate is implemented by epigenetic means based on demethylation of a single CpG site at −45 bp/−44 bp (CpG2) of the human IL18BP promoter. In contrast, retarded IL-18BP production in monocytic cells associates with C
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br Conclusion In this work experiments were carried out
2020-09-27
Conclusion In this work, experiments were carried out to purify the protein with COX activity, using an anti-mouse COX-2 pAb and a COX activity assay as tools for monitoring the protein responsible for this activity in the parasite. Gp63 enrichment through the affinity column and identification
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Khan et al studied the
2020-09-27
Khan et al. studied the effects of two structurally divergent coumarins viz calipteryxin 3 and (3′S,4′S)-3′,4′-disenecioyloxy-3′,4′-dihydroseselin 4 from Seseli recinosum, in lipopolysaccharide (LPS)-stimulated murine macrophages. The study revealed that calipteryxin and (3′S,4′S)-3′,4′-disenecioylo
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COMT expression protein level and activity are down
2020-09-27
COMT expression, protein level and activity are down regulated by E2. Using estrogen receptor (ER) positive MCF-7 cells, Xie et al. demonstrated an E2 dose dependent (1, 10 and 100 nM) decrease in S-COMT 1.3 kb mRNA that was maximum after 48 h (Xie et al., 1999). A similar decrease was not observed
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In BBR was reported to increase LDL receptor LDLR
2020-09-26
In 2004, BBR was reported to increase LDL receptor (LDLR) gene expression by stabilizing LDLR mRNA [4]. Following this report, the same groups conducted additional studies predominantly in HepG2 cells, with similar effects being observed [8], [11], [12], [4]. In addition to LDLR-mediated LDL cholest
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Plant uptake of P from OA could also be
2020-09-26
Plant uptake of P from OA could also be affected by arbuscular mycorrhizal fungi (AMF). Approximately 80% of terrestrial plant species form symbiotic associations with AMF (Smith and Read, 2010) which can enhance plant P uptake (Facelli and Facelli, 2002, Pearson and Jakobsen, 1993, Tibbett, 2000).
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There are conflicting studies on
2020-09-25
There are conflicting studies on ET axis and its relationship with clinicopathologic parameters in various cancers. Endothelin axis expression in the tissue and in blood has been associated with advanced cancer characteristics in colorectal, breast, and prostate cancer, while showing no linkage to c
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Recently a method for in vivo photoactivation
2020-09-25
Recently, a method for in vivo photoactivation of Diperodon HCl expressing PA-GFP in precise microanatomical compartments was described (Victora et al., 2010), which makes it possible to optically mark Tfh cells and track them 20 hr later (Shulman et al., 2013). Unexpectedly, it was reported that Tf
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br Substoichiometric substrate modification E
2020-09-25
Substoichiometric substrate modification E3 ligases catalyze the rapid transfer of the SUMOD from the E2 enzyme to the substrate. By definition, enzymes are recycled in the reaction, allowing multiple rounds of substrate modification by a single enzyme. Thus, enzymes function at substoichiometri
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Based on the SUMO SIM interaction involved in SUMOD position
2020-09-25
Based on the SUMO–SIM interaction involved in SUMOD positioning, a SUMO2ΔSBD (SIM-binding domain; Q30A, F31A, I33A) mutant can be investigated that disrupts this important binding interface (Eisenhardt et al., 2015; Meulmeester, Kunze, Hsiao, Urlaub, & Melchior, 2008). In Fig. 4A, multiturnover assa
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