• 12-O-tetradecanoyl phorbol-13-acetate br Conclusion br Intro

  2021-04-06

  

  Conclusion Introduction Biological wastewater treatment is targeted towards the removal of phosphorous, nitrogen and organic substances by the metabolic activity of a diverse activated sludge microbial community. More precisely, it is based on the versatile catalytic activity of the microbial

• br Acknowledgements We would like to thank Dr

  2021-04-06

  

  Acknowledgements We would like to thank Dr Ron Mason (NIEHS, Research Triangle Park, NC) for helpful discussion regarding the analysis of CCl4 metabolism, to Dr Karla Thrall and Dr Rick Corley (Battelle) for helpful discussions regarding study design and data interpretation, and to Jim Merdink an

• br Results br Discussion Taking

  2021-04-06

  

  Results Discussion Taking advantage of the highly specific protein–protein interactions among cognate Retapamulin that mediate SUMO conjugation to substrates, we have developed a novel strategy for achieving inhibition of SUMO conjugation in vivo based on disruption of SUMO E1–E2 interactions

• br Results br Discussion In

  2021-04-06

  

  Results Discussion In this paper we present insights into the observed specificities of inhibitors targeting the ubiquitin-activating and related E1 orexin receptor via crystal structures of the specific NEDD8-E1 inhibitor MLN4924, the dual NEDD8/Ub E1 inhibitor ABPA3, and the selective Ub-E1

• Support for Cloninger s personality theory

  2021-04-06

  

  Support for Cloninger's personality theory comes also from molecular genetic studies. Given the high heritability of personality it is plausible that gene variants explain variance in RD. In dna pk to endocrine studies, which relate hormone levels mostly in the periphery (blood, saliva, urine) to p

• For example nM MTX markedly

  2021-04-06

  

  For example, 200nM MTX markedly stimulates the differentiation of the monocytic U937 Gardiquimod mg [39], but only 10nM MTX is sufficient for the inhibition of clonogenicity in the ALL and APL cell lines [22]. Furthermore, an even lower concentration of MTX (2nM) selectively induces the expression

• In the growth of cereal seeds there are two

  2021-04-06

  

  In the growth of cereal seeds there are two phases, development and germination, separated by dormancy. The developmental phase contains the three following stages: 1. early development including double fertilization which results in the formation of the diploid embryo (by fusion of the egg cell wit

• Cytochromes P CYP are a superfamily

  2021-04-06

  

  Cytochromes P450 (CYP 450) are a superfamily of hemoproteins containing a heme cofactor, which are widely distributed in animals, plants and microbes (Hannemann et al., 2007). CYP450 exhibits a variety of biological functions including biotransformation of drugs, detoxification of endogenous and xen

• Immune modulation by steroid hormones is a rather

  2021-04-02

  

  Immune modulation by steroid hormones is a rather new aspect of the research on endocrine interactions in lower vertebrates (Harris and Bird, 2000). In the classical view, steroids exert their effects by binding to specific intracellular receptors that function as ligand-activated transcriptional re

• rock br Experimental Procedures br Acknowledgments br Introd

  2021-04-02

  

  Experimental Procedures Acknowledgments Introduction Bisphenol A (BPA), 2,2-bis (4-hydroxyphenyl) propane, is widely used to manufacture consumer products including food and beverage containers (Vandenberg et al., 2007). It can be accumulated in human body via leaching from the polymers int

• Synthesis of and is described in Scheme

  2021-04-02

  

  Synthesis of 5–7, 12–14, and 18 is described in Scheme 3. Compounds 5–7 and 18 were prepared as outlined in Scheme 3a. Reaction of 4-bromomethylbenzoic lpa receptor (36) with thionyl chloride yielded the corresponding acid chloride, which was converted to the corresponding amide 40a by the usual am

• br Materials and methods br Results br Discussion In

  2021-04-02

  

  Materials and methods Results Discussion In rodent species, CYP2E1 and CYP2B have been implicated in CCl4 metabolism. In this study, we used expressed human CYP2E1 to show that this enzyme is a high-affinity catalyst responsible for low-dose CCl4 metabolism. Studies employing an inhibitory

• Autoradiography studies have shown cerebellum to be devoid o

  2021-04-02

  

  Autoradiography studies have shown Sunitinib to be devoid of D1-R [40], confirming that this region may serve as reference for estimation of free and non-specifically bound radioligand concentration in tissue (= non-displaceable uptake). In initial human studies using [11C]SCH 23390 and [11C]NNC 112

• It is conceivable however that the distortion induced by

  2021-04-02

  

  It is conceivable, however, that the distortion induced by adozelesin in dsDNA may decrease the processivity of the translocating RecBCD enzyme so that it dissociates more frequently from adducted DNA relative to unmodified DNA. Premature termination from the DNA would also produce partially unwound

• br Enzymes repairing alkylated DNA br Induction of the Ada

  2021-04-02

  

  Enzymes repairing alkylated DNA Induction of the Ada regulon Methylated Ada is a strong activator for ada and alkA promoters. Although much weaker than the methylated form, unmethylated Ada acts alone as an activator for ada and alkA promoters. In contrast, the unmethylated protein present in

14465 records 660/965 page Previous Next First page 上5页 656657658659660 下5页 Last page