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Conventional configurations for alkanolamine and acid gas ar
2021-05-22
Conventional configurations for alkanolamine and Stiripentol receptor gas are not suitable to represent the chemical reaction between acid gas and alkanolamines. Nevertheless, Dowell et al. [17] have successfully represented the phase behaviour of CO2-water-MEA systems by using SAFT-VR [18] without
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bifonazole The evaluation of internal exposure in
2021-05-21
The evaluation of internal exposure in workers with omethoate is challenging. Unfortunately, OPs are metabolized and excreted quickly in the urine usually within 24–48 h of exposure, and the variation in metabolic rates exists. Many factors influence daily urinary output, such as salt intake, urea a
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Although the analysis described above goes
2021-05-21
Although the analysis described above goes far to explain the mechanism of Fungicidin perturbations through CHK1 inhibition, it raises important questions about the mechanism by which WT RAS isoforms promote CHK1 S280 phosphorylation. Previous reports have shown that both the MAPK-RSK and PI3K-AKT
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Rufinamide receptor In this work we fabricated a
2021-05-21
In this work, we fabricated a kind of multifunctional nanoparticles, based on HAuNS coated by chitosan-stearic Rufinamide receptor copolymer (CSO-SA), which was employed frequently to form micelles for hydrophobic drug delivery in our previous work [21], [22]. The nanoparticles can encapsulate DiR
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The Liver X Receptor and LXRs NR H and NR
2021-05-21
The Liver X Receptor-α and -β (LXRs, NR1H3 and NR1H2, respectively) are members of the nuclear receptor superfamily that play a central role in controlling cholesterol homeostasis [9], [10]. In macrophages, LXRs can decrease the cellular sterol burden by inducing expression of the cholesterol efflux
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The contribution of local ETA and ETB receptors towards
2021-05-21
The contribution of local ETA and ETB receptors towards heat hyperalgesia induced by inoculation of XC tumor SynaptoRedTM C2 in the paw of mice has been demonstrated by Baamonde and colleagues (Baamonde et al., 2004). Furthermore, using neuropathic and inflammatory nociception models, several stud
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ARCA Cy5 EGFP mRNA In the present study real
2021-05-21
In the present study, real-time polymerase chain reaction also confirmed that gene expressions of RT1 class II, locus Bb (RT1-Bb) was up-regulated and Spi-B transcription factor (Spib) was downregulated at day 3 after the VMH lesions. These two genes work as one of immune responses. RT1-Bb controls
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A potential weakness of the
2021-05-21
A potential weakness of the present study is that it involved population controls rather than family controls, which are a better way of controlling the effects of population stratification (e.g. ethnic group differences in allele frequencies). On the other hand, general population samples do have t
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br UVC induced DNA damage a model to
2021-05-21
UVC-induced DNA damage: a model to study DNA damage tolerance The UV components of sunlight that reaches the Earth surface are one of the most carcinogenic agents humans are exposed to, and the leading cause of skin cancer [4,12]. UV light causes different types of DNA damage through indirect and
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We also determined the uracil content of CJ
2021-05-21
We also determined the uracil content of CJ236 DNA by thin-layer chromatography of in vivo32P- or [6-3H]uracil-labeled CJ236 2′-deoxyribose 5′-monophosphates as well as by LC/MS of deoxyuridine and thymidine 2′-deoxynucleosides (Table 1, Table 2, Table 3). Examination of the 32P data showed that, ba
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br Concluding Remarks Synthetic cytokine
2021-05-21
Concluding Remarks Synthetic cytokine biology has become an important research area with novel solutions and ideas for therapeutic approaches, for example, synthekines, fusokines, immunocytokines, neoleukins, MESA receptors, or synthetic Notch or cytokine receptors. In addition to their huge impa
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The importance of G S
2021-05-21
The importance of G1–S phase progression to the formation of malignant tumors has been highlighted by the high incidence of aberrations in the genes involved in this progression in a wide variety of tumors. p27Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors (CKI). Its ro
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Estrogen receptors ERs belong to
2021-05-20
Estrogen receptors (ERs) belong to the third class of nuclear receptors (NR3) [23]. Two different forms of ER have been described, ERα and ERβ. They are coded by two distinct genes (ESR1 and ESR2, respectively) containing 8 transcribed exons that give rise to six conserved protein domains: domains A
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Proinflammatory cytokines induce ER stress in many
2021-05-20
Proinflammatory cytokines induce ER stress in many mammalian cell systems.32, 33, 34 Our results demonstrate that these cytokines also trigger ER stress in trophoblast JEG-3 cells. However, the severity of stress is likely low grade because only the PERK-EIF2A arm of the UPRER pathway was activated.
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The development of novel approaches to
2021-05-20
The development of novel approaches to study GPCR-mediated transactivation in live OSI-930 is important, and this study describes a unique BRET-based quantification of Grb2 recruitment to the EGFR as a direct readout of GPCR-mediated transactivation. We have previously used the recruitment of Grb2
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