• However despite medicinal chemistry efforts

  2022-01-17

  

  However, despite medicinal chemistry efforts lead to considerable improvement in potency and selectivity of new HO-1 inhibitors, still have not identified inhibitors in the low nanomolar range. Therefore, due to the possible in vivo non-specific effects at high dosage, novel strategies should be dev

• Distribution of Iodine labeled ANP I

  2022-01-17

  

  Distribution of 125Iodine-labeled-ANP (125I-ANP) radioactivity on the cell surface, in the intracellular compartments, and in culture medium established a dynamic equilibrium of receptor-mediated 125I-ANP uptake, degradation, and release outside of HU 308 receptor (Fig. 2). A major proportion of in

• As well as the above studies Meier and

  2022-01-17

  

  As well as the above studies, Meier and coworkers used TUG-891, alongside omega-3 fatty acids, to show a potential role for FFA4 in inhibiting proliferation of DU145 prostate cancer cells [68]. Given that these cells express both FFA4 and FFA1 and the current view that TUG-891 may not be sufficientl

• Thus synthesized thienopyrimidine derivatives were

  2022-01-17

  

  Thus synthesized thienopyrimidine derivatives were evaluated in vitro for GPR119 agonistic activity, and the results are summarized in , , . First, we fixed the 4-methylsulfonylphenyl substituent at the R position on the thienopyrimidine ring, and derivatized at the R position. As shown in , and s

• br Disclosure statement br Acknowledgements We thank Dr Rona

  2022-01-17

  

  Disclosure statement Acknowledgements We thank Dr. Rona Carroll for her contribution to the preparation of the manuscript and Dr. Iosif Pediaditakis for his contribution to the preparation of the figures. This work was supported by NIHR01 HD019938 to U.B.K. Introduction The mammalian hypot

• br Materials and methods br Results br Discussion

  2022-01-17

  

  Materials and methods Results Discussion Conclusion Pharmacophore modeling was applied to explore new probable Glo-I inhibitors. Ninety two pharmacophoric models were generated representing diverse types of interaction between co-crystallized ligands and corresponding binding site. The g

• Introduction Carbohydrates are some of the most stereochemic

  2022-01-17

  

  Introduction Carbohydrates are some of the most stereochemically complex biological molecules found in nature. In addition to their energetic and structural roles in living systems, their role when covalently linked to proteins is critically important in a myriad of molecular recognition processes.

• br Funding This work was supported by the Deutsche Forschung

  2022-01-17

  

  Funding This work was supported by the Deutsche Forschungsgemeinschaft (SFB766 and GRK1708). Conflict of interest Acknowledgements Introduction Hepatitis C virus (HCV) infection is a global problem affecting about 3% of the world’s population [1], [2]. Mother-to-child transmission of HC

• br Concluding remarks br Introduction The hair cells

  2022-01-17

  

  Concluding remarks Introduction The hair Tacalcitol receptor of vestibular organs detect linear and rotational head movements, providing sensory information that is essential for normal postural and visual reflexes. Most vestibular hair cells are produced during embryonic development, but they

• br Biologically active non peptide galanin receptor

  2022-01-17

  

  Biologically active non-peptide galanin receptor ligands The first successful attempt in overcoming these weaknesses was undertaken by Saar et al. (2002). Screening of galanin sequence established that Trp-2, Asn-5, Tyr-9 were pharmacophores, responsible for biochemical action of the peptide. Bas

• Introduction Osteoclasts are large multinuclear cells

  2022-01-17

  

  Introduction Osteoclasts are large, multinuclear Sephin 1 that are responsible for the resorption (breakdown) of bone [1]. Together with osteoblasts, the bone forming cell, they maintain the integrity of the skeleton through constant resorption and repair of bone. Osteoclast precursors of monocytic

• JNJ-26854165 br G protein coupled receptor

  2022-01-17

  

  G-protein coupled receptor 40 (GPR40), also known as a free fatty JNJ-26854165 receptor, is dominantly expressed in pancreatic β cells and intestine K, L cells., . Besides, GPR40 is also reported to be expressed in brain, but its function is still unknown. It is well documented that GPR40 agonist

• To meet the requirement of ferroptosis

  2022-01-17

  

  To meet the requirement of ferroptosis-based therapy, a couple of small molecule drugs and nanomaterials were introduced to the design of ferroptosis inducers, separately. As we know, iron is a key regulator of ferroptosis. When small molecule drugs are employed to induce ferroptosis, the endogenous

• br Acknowledgments We thank Prof Alexander D Johnson and

  2022-01-15

  

  Acknowledgments We thank Prof. Alexander D. Johnson and Suzanne M. Noble for kindly providing SN strains. This work was supported by Chinese National Natural Science Foundation Grants 31370105 and 31300057, and Shanghai STCSM Grant 12JC1409300. Introduction Organisms modulate gene expression

• Electrochemical techniques have attracted broad

  2022-01-15

  

  Electrochemical techniques have attracted broad attention for their outstanding advantages, such as satisfactory sensitivity and convenient operation. Nowadays, nucleic caspofungin nanostructures such as DNA tetrahedron structure, nucleic acid-mimicking structure, exhibit noticeable application in

14203 records 472/947 page Previous Next First page 上5页 471472473474475 下5页 Last page