• Now we turn to the other channel through which the

  2022-02-18

  

  Now we turn to the other channel through which the risk-taking incentives provided by option compensation affect corporate debt maturity. Jensen and Meckling (1976) argue that the payoff structure of debt holders in a levered firm is concave, while that of equity holders is convex, thus, shareholder

• Another important question for future studies will

  2022-02-18

  

  Another important question for future studies will be whether FAAH inhibitors work to normalize impairments in fear extinction that are known to be produced by environmental insults such as exposure to abused drugs and stress 97, 103. Indeed, several authors have posited utility of FAAH inhibitors f

• We examined the expression of notch

  2022-02-18

  

  We examined the expression of notch-1 in the brains of mice following morphine or oxycodone tolerance. The results showed that notch-1 levels did not change following morphine or oxycodone tolerance, with or without the treatment of IRL-1620. This indicates the possibility that morphine or oxycodone

• Allergic rhinitis characterized by inflammation of the

  2022-02-18

  

  Allergic rhinitis, characterized by inflammation of the nasal membrane, results from an over-activated immune system exposed to AZD8055 in sensitized individuals, and is associated with nasal congestion, rhinorrhea, sneezing, and pruritus. As histamine is a key mediator in triggering allergic rhini

• Ultimately the change of maturation ratio of the Leydig cell

  2022-02-17

  

  Ultimately, the change of maturation ratio of the Leydig cell caused reducing of INSL3 expression undoubtedly. INSL3 (insulin-like 3) is a hormone produced mainly in gonadal tissues. It was discovered to participate in development of urogenital tract. The mutations of this gene is one cause of crypt

• br Direct effect of HDACs on

  2022-02-17

  

  Direct effect of HDACs on contractile function by deacetylating cytoskeletal and contractile proteins Role of HDACs in electropathology by transcriptional reprogramming Next to deacetylation of α-tubulin by HDAC6 in experimental and human AF, there is also evidence for transcriptional reprogra

• br Methods br Results br Discussion The aim

  2022-02-17

  

  Methods Results Discussion The aim of this study was to investigate whether serum lectin-binding activity is associated with development of HCC in HCV-positive individuals. Using ELISA-based assays of lectin-binding activity, we demonstrated that both age and gender influence the circulatin

• It is difficult however to assure that observed

  2022-02-17

  

  It is difficult, however, to assure that observed alterations of pro-oxidant/antioxidant levels within the studied organisms are related directly to heavy metal pollution, rather than to other accompanying environmental stressors. Environmental factors like oxygen partial pressure, temperature, sali

• br Future perspectives sGC signaling is important in the mai

  2022-02-17

  

  Future perspectives sGC signaling is important in the maintenance of multiple physiological functions. sGC is localized to cell membranes with both sGC Cys modifications and heme regulation identified as the crucial components in regulating sGC activity. Specifically, S-nitrosation of several com

• To shed more light on the binding

  2022-02-17

  

  To shed more light on the binding of benzophenanthridine to GlyT1, we studied how the replacement of certain residues around the sanguinarine sensitive cysteine 475 previously identified (Jursky et al., 2012) affects GlyT1 inhibition of by these alkaloids. Based on these results we propose a putativ

• br Conclusion br Acknowledgments br Introduction The gyloxal

  2022-02-17

  

  Conclusion Acknowledgments Introduction The gyloxalase pathway is a well-conserved antioxidant defense system found in all cells of the body [1], [2], [3], [4]. The glyoxalase pathway facilitates the neutralization of highly reactive and oxidizing dicarbonyl molecules, with methylglyoxal (M

• Previous reports have showed that the

  2022-02-17

  

  Previous reports have showed that the expression and localization of GLUT8 in mouse (Gómez et al., 2006; Kim and Moley, 2007), rat (Ibberson et al., 2002) and human (Schürmann et al., 2002). In this study, GLUT8 protein mainly localized in the spermatocytes, elongated and round spermatids in the adu

• Work in the Ruiz i Altaba lab

  2022-02-17

  

  Work in the Ruiz i Altaba lab was funded by grants from the Swiss National Science Foundation, the Ligue Suisse Contre le Cancer, the European FP7 Marie-Curie Initial Training Network HEALING, a James McDonnell Foundation 21st Century Science Initiative in Brain Cancer-Research Award and funds from

• In fact changes in mitochondrial

  2022-02-17

  

  In fact, changes in mitochondrial dynamics directly affects many things including cellular metabolism [127], mitochondrial mass and turnover [128], mitochondrial transport, and calcium buffering [129]. Nigrostriatal DA neurons seem to have a preferential susceptibility to loss of Mfn2 when compared

• The focused set of cyclopentapyrazoles produced six

  2022-02-17

  

  The focused set of cyclopentapyrazoles produced six compounds with sufficient activity to warrant the evaluation of kinetic solubility. Despite the improved activity of the series, these compounds remain stalwartly insoluble (), indicating the need for additional chemical modifications which address

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