• br Introduction HH GLI signaling is one of

  2022-03-22

  

  Introduction HH-GLI signaling is one of the major pathways involved in both normal and neoplastic development [[1], [2], [3], [4]]. Inappropriate activation of this pathway has been linked to cancer, including medulloblastoma, rhabdomyosarcoma, basal cell carcinoma and cancers of the lung, stomac

• Although GLP has greater insulin

  2022-03-22

  

  Although GLP-1 has greater insulin-releasing effects at pharmacological concentrations [10], it is apparent that the higher circulating concentrations of GIP combined with more pronounced increase in secretion following feeding make GIP the major physiological incretin [7], [11]. The peptide exerts

• Two types of processes intrinsic

  2022-03-22

  

  Two types of processes, intrinsic and extrinsic, contribute synergistically to the age-related change on structural integrity and physiological function of the skin (Farage, Miller, Elsner, & Maibach, 2008). Intrinsic aging arise from genetically programmed cell aging, normal metabolic activities, a

• br Methods and materials br Results br Discussion

  2022-03-22

  

  Methods and materials Results Discussion In this study we demonstrate that CF epithelial Trelagliptin exhibit features of apoptosis in their basal, unstimulated state including increased caspase (-3 and -8) activation compared to non-CF epithelial cells. Analysis of factors responsible for

• In general the FDP gene is

  2022-03-22

  

  In general the FDP gene is involved in isoprenoid biosynthesis for normal growth and development of plant species while it is specifically involved in rubber biosynthesis (cis-1,4-polyisoprene units) in Hevea plant. When the HbFDP gene was over-expressed under the control of constitutive promoter in

• The present findings demonstrate for

  2022-03-22

  

  The present findings demonstrate for the first time in immature rats that hippocampal infusion of ET-1 results in a rapid and long-lasting decrease in regional cerebral blood flow (rCBF) and oxygen saturation (pO2). These data are in accord with the results of studies and adult animals, which have s

• Literature review suggests a strong

  2022-03-22

  

  Literature review suggests a strong presence of central histaminergic transmission in the Asiatic acid areas targeted by caffeine to induce its behavioral actions. Interestingly, it is reported that caffeine administration increases the histamine neuronal activation and release of histamine in the

• In an effort to further improve the intrinsic

  2022-03-21

  

  In an effort to further improve the intrinsic potency, we evaluated the effect of the C4-substituent of the triazole (). Replacement of the phenyl group with a cyclohexyl or with a 2-pyridyl substituent led to losses in potency. Increasing the size of the substituent to a bi-phenyl or naphthyl gr

• To maintain low Glu concentrations in the synaptic cleft

  2022-03-21

  

  To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino rho inhibitor is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocytes, and

• To get a broader view of the interplay

  2022-03-21

  

  To get a broader view of the interplay between glycolysis and Hippo signaling, we tested the involvement of YAP1 in the regulation of C-MYC and GLUT1 expression. We were able to detect a YAP1-TEAD1 interaction in the nuclear fraction of Jurkat jnk pathway and confirm the inhibition of this interact

• br Introduction The glucagon receptor

  2022-03-21

  

  Introduction The glucagon receptor (GCGR) is a G-protein-coupled receptor expressed mainly in the liver and kidney. Upon glucagon binding, it activates the stimulatory G protein (Gs) and increases cAMP level, subsequently transducing glucagon signaling involved in glucose, amino acids and lipid m

• br Materials and methods br

  2022-03-21

  

  Materials and methods Results Discussion Our study demonstrates that human GIP(3-30)NH2 is a selective GIPR antagonist that inhibits both GIP-mediated cAMP signaling, β-arrestin recruitment, and GIPR internalization. Furthermore, we demonstrate that human GIP(3-30)NH2 binds with high affini

• Studies regarding secretase nowadays aim at elucidating

  2022-03-21

  

  Studies regarding γ-secretase nowadays aim at elucidating how APP is recognized and recruited. It has been suggested based on coarse-grained molecular simulation that the recognition and recruitment of substrate can occur on an extended surface covering PS1's TM2/6/9 domains and PAL motif [15]. Tran

• br Declarations of interest br Acknowledgements This work

  2022-03-21

  

  Declarations of interest Acknowledgements This work was supported by the National Natural Science Foundation of China (81673321, 21506099), the State Key Laboratory of Drug Research (SIMM1705KF-13), the Natural Science Foundation of Jiangsu Province (Grant No. BK20151541), and the Jiangsu Syne

• In Arabidopsis GCN containing protein complexes are found to

  2022-03-18

  

  In Arabidopsis, GCN5-containing protein complexes are found to be involved in cell differentiation, leaf and floral organogenesis [[8], [9], [10]]. AtHAC1 has involvement with root elongation, flowering, fertility and de novo shoot regeneration [11,12]. AtHAM1 and AtHAM2 control flowering time by ep

14198 records 435/947 page Previous Next First page 上5页 431432433434435 下5页 Last page