• The present data suggest that the decrease

  2022-05-05

  

  The present data suggest that the decrease of liver BAs was mainly due to the decrease of hepatic BAs synthesis because the BA synthetic enzymes Cyp7a1, Cyp7b1 and Cyp8b1 were markedly reduced. The increase may also be due to the increase of hepatic BAs efflux, because the liver BA efflux transporte

• Ning et al showed that LPC

  2022-05-05

  

  Ning et al. showed that LPC 18:1 appeared to increase insulin release through both GPR119-dependent and -independent mechanisms (Ning et al., 2008). In our study, we have shown that not only GPR119 but also GPR40 and GPR55 participate in LPC-stimulated insulin secretion (Fig. 4, Fig. 5) and target p

• The improved glucose tolerance of Ffar R W R

  2022-05-05

  

  The improved glucose tolerance of Ffar1R258W/R258W mice on HFD was unexpected. In combination with similar fasting blood glucose levels, the significant lower fasting plasma insulin of mutant mice compared to wild-type mice is indicative of improved insulin sensitivity. However, peripheral insulin r

• br Conflict of interest br

  2022-05-05

  

  Conflict of interest Acknowledgments The research was funded by the Major Programs of Pharmaceutical research project of Jiangsu Province (Q2018044). Introduction Lipids are important regulators of cell death. In mammalian cells, both apoptotic and non-apoptotic cell death pathways can be

• br Acknowledgments We apologize to the researchers who

  2022-05-05

  

  Acknowledgments We apologize to the researchers who were not referenced due to space limitations. We thank Dave Primm (Department of Surgery, University of Texas Southwestern Medical Center) for his critical reading of the manuscript. This work was supported by grants from the US National Institu

• Potential platelet related mechanisms that might explain

  2022-05-05

  

  Potential platelet-related mechanisms that might explain an augmented risk of MI in dabigatran treated patients have been investigated: Enhanced platelet reactivity is known to be associated with the risk of MI (Mangiacapra et al., 2018) and catalytically active thrombin is a potent stimulus to indu

• br Materials and methods br Results and discussion br

  2022-05-05

  

  Materials and methods Results and discussion Conclusion The as-designed system was based on the assembly of MSN-Cy and TPGS, which was dominated by π-π stacking interactions. By the strong mutual force, Cypate and TPGS formed a compact layer around the MSN core, which blocked the drug leaka

• br Concluding Remarks One of the remarkable features of Hipp

  2022-05-05

  

  Concluding Remarks One of the remarkable features of Hippo signaling is its sensitivity to the cytoskeleton and mechanical forces. Progress has been made recently in identifying molecular mechanisms by which the cytoskeleton can influence Hippo signaling, but among the many outstanding questions

• Wolf et al then proceed to interrogate the

  2022-05-05

  

  Wolf et al. (2016) then proceed to interrogate the mechanism by which NAG activates the NLRP3 inflammasome. When examining potential triggers previously implicated in NLRP3 activation, they found that both PGN and NAG trigger appearance of mitochondrial DNA (mtDNA) in the cytosol, which led them to

• Wolf et al then proceed to interrogate the

  2022-05-05

  

  Wolf et al. (2016) then proceed to interrogate the mechanism by which NAG activates the NLRP3 inflammasome. When examining potential triggers previously implicated in NLRP3 activation, they found that both PGN and NAG trigger appearance of mitochondrial DNA (mtDNA) in the cytosol, which led them to

• Hypoxia HIF and Inflammation Cellular responses to hypoxia a

  2022-05-05

  

  Hypoxia, HIF, and Inflammation Cellular responses to hypoxia are essential for life and are now recognized to be dysregulated in a wide range of disease processes. The key players in these pathways are a family of transcription factors, the hypoxia-inducible factors (HIFs; see Glossary), as well as

• The site of metastasis in breast

  2022-05-04

  

  The site of metastasis in breast cancer often contributes to the patient’s OS. Patients with bone metastasis from their breast cancer often have a notably increased survival over patients with visceral or Pefloxacin metastasis. In this analysis, ER+/HER2+ patients were noted to have a higher rate o

• Efficiency of methylated process was assessed by

  2022-05-04

  

  Efficiency of methylated process was assessed by calculating PMI and SMI. On average, PMI was 0.9 and ranged from 0.1 to 3.8 while SMI was 4.9 and ranged from 0.3 to 21.3. The observed differences in the arsenic methylation can be associated with the inter-individual variations caused by a genetic p

• br Conclusions br Introduction Astrocytes contribute to phys

  2022-05-04

  

  Conclusions Introduction Astrocytes contribute to physiological no one care function on many levels. They help maintain the physiological composition of the extracellular medium by, for instance, buffering potassium and uptake of neurotransmitters. They can also provide neurons with energy su

• br Discussion In the present paper it was shown for

  2022-05-04

  

  Discussion In the present paper it was shown for the first time that the conjugation of ethacrynic Rofecoxib and glutathione catalyzed by GSTP1-1 stereospecifically forms one of the diastereoisomers of the glutathione conjugate (EASG). Chemical conjugation results in formation of a mixture of bo

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