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In our cohort each patient
2022-09-03
In our cohort, each patient had a median of 2 Anti-FXa measurements performed daily and a median of 1 infusion rate change daily to maintain therapeutic unfractionated heparin levels. Previously, several studies have documented that APTT-based protocols lead to more fluctuations in comparison with A
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Our observation of LPS induced increase in the
2022-09-03
Our observation of LPS-induced increase in the sensitivity of cultured endothelium-intact coronary TAK-285 towards stimulation with selective ETB receptor agonist (S6c) could be explained by activation of TLRs receptors located on the endothelium of rat coronary arteries. However, the possible recr
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br Acknowledgments We would like to thank
2022-09-03
Acknowledgments We would like to thank Coordenação de Aperfeiçoamento de Pessoal do Ensino Superior (CAPES) and Conselho Nacional de Desenvolvimento Cientifico e Tecnológico (CNPq) for the grants and scholarships provide to the authors of this work. Introduction Human Immunodeficiency Virus t
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Introduction Protein tyrosine phosphorylation plays key role
2022-09-03
Introduction Protein-tyrosine phosphorylation plays key roles in a variety of intracellular signaling pathways involved in cell proliferation, differentiation, gene expression, cell adhesion, and metabolic changes [1]. While receptor-type tyrosine kinases localize to the plasma membrane, most of no
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Not only does G a GLP complex appear to play
2022-09-03
Not only does G9a/GLP complex appear to play a role (albeit a seemingly conflicting one) in LTP maintenance, it may also be involved in long-term depression (LTD) (). At hippocampal CA1 synapses, LTD can be induced by pharmacological or synaptic stimulation of Group 1 metabotropic glutamate receptor
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Multiple subsets of Breg cells in mice have been identified
2022-09-03
Multiple subsets of Breg cells in mice have been identified that could suppress the T cell-mediated response. However, a lack of consensus surface markers for Breg cells made it difficult to judge whether Breg cells are a special B cell subset or whether all AMG232 have an immuno-regulatory functio
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Isorhamnetin Taken together this study provides the proof of
2022-09-02
Taken together, this study provides the proof of concept that our novel heterologous human/rat HER2-specific T cell vaccine HuRt-TEXO, which is capable of stimulating both humoral and CTL responses leading to potent antitumor immunity through the circumvention of HER2 tolerance in double transgenic
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Isorhamnetin Taken together this study provides the proof of
2022-09-02
Taken together, this study provides the proof of concept that our novel heterologous human/rat HER2-specific T cell vaccine HuRt-TEXO, which is capable of stimulating both humoral and CTL responses leading to potent antitumor immunity through the circumvention of HER2 tolerance in double transgenic
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STAR Methods br Acknowledgments We thank
2022-09-02
STAR★Methods Acknowledgments We thank C. Hong, R. Huang, and Z. Yu at the HHMI Janelia cryo-EM facility for help with microscope operation and data collection. We thank A. Müller, W. Kan, and W. Weis for help with the SEC-MALS analysis and M. Elazar and J. Glenn for the use of equipment. P. Love
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It is difficult however to assure that observed alterations
2022-09-02
It is difficult, however, to assure that observed alterations of pro-oxidant/antioxidant levels within the studied organisms are related directly to heavy metal pollution, rather than to other accompanying environmental stressors. Environmental factors like oxygen partial pressure, temperature, sali
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br Modulators of the GUCY C cGMP
2022-09-02
Modulators of the GUCY2C/cGMP/PDEs signaling pathways for CRC prevention and therapy (pre-clinical and clinical development) Several modulators of the GUCY2C/cGMP/PDEs signaling pathways, including GUCY2C agonists and PDEs inhibitors, have been developed and explored as chemopreventive agents for
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br Ketone body metabolism and neuronal excitability
2022-09-02
Ketone body metabolism and neuronal excitability One of the best examples of the close connection between metabolism and neuronal excitability is illustrated by the effect of ketone bodies on epileptic seizures. One third of patients suffering from epileptic seizures do not respond to conventiona
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Abn CBD induced changes reduced microglial cell density cell
2022-09-01
Abn-CBD induced changes (reduced microglial cell density, taselisib size and a lower density of ramification) in the microglial morphology that could be compatible with a blockade of the neuroinflammation provoked by MPTPp. The absence of GPR55 transcripts in microglial cells in striatum and the si
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The average pregnancy rate in this
2022-09-01
The average pregnancy rate in this work was 60.1%; similar results have been reported with the same estrus synchronization treatment (58% pregnancy rate) [26]. Later studies also showed that the pregnancy rate was 56.9 and 51.1%, with FTAI and estrous detection, respectively [34,35]. Although that t
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Growing evidence suggests that the glycine
2022-09-01
Growing evidence suggests that the glycine site seems to play a pivotal role in NMDAR-related function. For example, it Epidermal Growth Factor (EGF), human recombinant has been demonstrated in a hippocampal slice study that the glycine site sub-serves the spatiotemporal detection of synaptic activ
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