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br Method of literature search br Disclosures br Acknowledgm
2023-02-06
Method of literature search Disclosures Acknowledgment The authors thank and acknowledge Mrs. Jaini Parekh, BFA, for illustrating the diagram in Figure 1. An overview of angiogenesis Angiogenesis is a biological process through which there is the formation of new blood vessels from pre-
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In the present study AP
2023-02-06
In the present study, AP31-B preferentially released hydrophobic NSC228155 such as leucine and alanine from N-terminal of peptide (Fig. 4). The debittering ability of AP31-B seemed to depend on such substrate specificity, but additional tests against other hydrophobic amino acids are needed to conf
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Recently rather than predicting categorical variables as
2023-02-06
Recently, rather than predicting categorical variables as in classification, several studies begin to estimate continuous clinical variables from Folinic acid synthesis images. Therefore, instead of classify a subject into binary or multiple pre-determined categories or stages of the disease, regres
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Sphingolipids such as ceramides and glucosylceramides are
2023-02-06
Sphingolipids, such as ceramides and glucosylceramides, are an important class of bioactive lipids. The levels of these lipids change as a function of adipose tissue mass and functionality, and are partially driven by cellular availability of palmitoyl-CoA. Aberrant accumulation of ceramide, glucosy
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The ARHL locus ahl that contributes to the
2023-02-06
The ARHL locus (ahl) that contributes to the hearing loss in the C57BL/6J mouse has been mapped to chromosome 10 (Erway et al., 1993, Johnson et al., 1997). It has been shown that strains susceptible to early onset ARHL carry a specific mutation in the cadherin 23 gene (Cdh23), which encodes a compo
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Acknowledgments br Introduction Prostate cancer is
2023-02-01
Acknowledgments Introduction Prostate cancer is the first leading cause of cancer-related deaths among males in the UK and the second in the US. Despite recent advances in surgery, radiation, medical management and screening, prostate cancer patients suffer high morbidity and mortality and signi
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Loss of virulence in ACL mutants may be
2023-02-01
Loss of virulence in ACL mutants may be caused by defect in vegetative growth and conidial germination, and reduced trichothecene production. However, supplement of potassium acetate restored the defects in germination rate and vegetative growth, but not virulence in wheat heads (Table 2, Fig. 2B),
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br Results br Discussion Both ATM
2023-02-01
Results Discussion Both ATM and ATR are key regulators of the cellular response to DSBs, yet how exactly they function in concert is not well understood. Recent studies revealed that ATM is required for the resection of DSBs (Jazayeri et al., 2006, Myers and Cortez, 2006), a process necessary
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br In vivo visualization of aromatase
2023-02-01
In vivo visualization of aromatase with positron emission tomography (PET) Positron emission tomography (PET) utilizes the high Canine HGF / Hepatocyte Growth Factor Protein photons formed during the annihilation of positrons to detect the changes in the amount and localization of injected radi
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Additionally we used the predicted Cyp a
2023-02-01
Additionally, we used the predicted Cyp19a1b amino Metformin sequence from a number of bony fish species to infer their genetic relatedness and found that R. quelen occupies an ancient position within the Siluriformes group. A phylogenetic tree was constructed and it included both full-length and p
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Whereas allostery in the cell is relatively
2023-02-01
Whereas allostery in the β cell is relatively understudied, significant progress has been made in understanding the physiology and mechanistic biology of how AMPK and its upstream kinases govern β cell function. LKB1 phosphorylates AMPKα at Thr172 [21], and loss of LKB1 in β cells abolishes phosphor
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muscle metabolism br Materials and methods br Results br
2023-02-01
Materials and methods Results Discussion Knowledge of the molecular basis of an inherited genetic disease is crucial for understanding the disease pathology and, ultimately, for therapeutic design. Several recent reports have stressed the need for physical characterization of disease-associ
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br Conflict of interest br Introduction The Piezo proteins P
2023-02-01
Conflict of interest Introduction The Piezo proteins, Piezo1/FAM38A and Piezo2/FAM38B, are multi-pass transmembrane proteins that have been identified as mechanically-activated (MA) homomultimeric, pore-forming ion channels [1,2]. Piezo1 is broadly expressed with its highest expression in blad
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br Conclusion br Conflict of interest br Introduction Oral c
2023-02-01
Conclusion Conflict of interest Introduction Oral cancer may originate from lips, lower and upper alveolar ridges, hard palate, sublingual region, buccal mucosa, anterior two-thirds of the tongue as well as retromolar trigone and floor of the mouth (World Health Organization, 2013). As the
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AdipoRon is an orally active synthetic
2023-02-01
AdipoRon is an orally active, synthetic small molecule that activates adiponectin receptor (AdipoR). It mimics the antidiabetic effects of adiponectin, exhibiting its effect through the activation of AMPK and PPARα pathways via AdipoR1 and AdipoR2, respectively (Fig. 2) [62]. AdipoR activation has r
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